The Battle of Issus
Darius III flees, leaving his family and treasury to Alexander

On 5 November 333 BC Alexander the Great first faced Darius III in person, in a narrow valley by the Gulf of Issus, and routed the Persian army. Darius fled, leaving his mother, wife, children and treasury in the camp; the way to Syria, Phoenicia and Egypt lay open.
Wikipedia (Russian) · Wikipedia (English) · 4th century BC
Meanwhile around the world (±25 years)
Europe
- 338 BC The Battle of Chaeronea — 5 years earlier
Africa
- 331 BC Founding of Alexandria — 2 years later
Asia
- c. 322 BC Founding of the Maurya Empire — 11 years later
Alive at the time
- Aristotle (aged 51)
- Alexander the Great (aged 23)
- Mencius (aged 39)
- Epicurus (aged 8)
- Chandragupta Maurya (aged 7)
- Diogenes of Sinope (aged 79)
- Olympias (aged 42)
- Zhuangzi (aged 36)
- Ptolemy I Soter (aged 34)
- Pyrrho (aged 27)