Wei conquers Shu
The first of the Three Kingdoms falls as Liu Shan yields Chengdu

In 263 the Wei generals Zhong Hui and Deng Ai invaded Shu; Deng Ai bypassed the border forts by mountain paths and appeared before Chengdu, and Emperor Liu Shan surrendered. Two years later Sima Yan deposed the last Wei ruler and founded the Jin empire.
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Meanwhile around the world (±25 years)
Europe
- 260–274 Postumus founds the Gallic Empire — 3 years earlier
Middle East
- c. 240 Mani begins to preach — 23 years earlier
- 260 Battle of Edessa: a Roman emperor taken captive — 3 years earlier
Africa
- 249–262 Plague of Cyprian — 14 years earlier
Americas
- c. 250 Rise of the Classic Maya cities — 13 years earlier
Alive at the time
- Plotinus (aged 59)
- Zenobia (aged 23)
- Anthony the Great (aged 12)