Sack of Rome
The Emperor's mercenaries ravage the Eternal City

On 6 May 1527 unpaid, mutinous landsknechts and Spanish soldiers of Charles V stormed Rome. Pope Clement VII took refuge in Castel Sant'Angelo while the city was plundered for months; the year is often seen as the end of the High Renaissance in Rome.
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Meanwhile around the world (±25 years)
Whole world
- 1526–1867 Atlantic slave trade — 1 year earlier
Eastern Europe & Russia
- 1514 Capture of Smolensk — 13 years earlier
- 1547 Ivan IV crowned Tsar — 20 years later
Middle East
- 1520–1566 Reign of Suleiman the Magnificent — 7 years earlier
Africa
- 1529–1543 Ahmad Gragn invades Ethiopia — 2 years later
Asia
- 1510 Portugal takes Goa — 17 years earlier
- 1511 Portuguese capture of Malacca — 16 years earlier
- 1526 First Battle of Panipat — 1 year earlier
Americas
- 1519–1522 Magellan's circumnavigation — 8 years earlier
- 1521 Fall of Tenochtitlan — 6 years earlier
- 1532 Capture of Atahualpa at Cajamarca — 5 years later
- 1542 Orellana sails down the Amazon — 15 years later
- 1545–1548 Cocoliztli epidemic — 18 years later
Alive at the time
- Nicolaus Copernicus (aged 54)
- Michelangelo (aged 52)
- Martin Luther (aged 44)
- Erasmus (aged 61)
- Guru Nanak (aged 58)
- Niccolò Machiavelli (aged 58)
- Vasily III (aged 48)
- Babur (aged 44)
- Bartolomé de las Casas (aged 43)
- Hernán Cortés (aged 42)